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Article

Taking a "good" look at free radicals in the aging process.

Trends in cell biology - 1 Oct 2011

Hekimi Siegfried, Lapointe Jérôme, Wen Yang

Abstract excerpt

The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based on the observed association of the rate of aging and the aged phenotype with the generation of ROS and oxidative damage. However, recent findings, in particular in Caenorhabditis elegans but also in rodents, suggest that ROS generation is...

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Identifiers

PMID: 21824781
DOI: 10.1016/j.tcb.2011.06.008
PMCID: PMC4074523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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