Article
IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells.
The Journal of allergy and clinical immunology - 1 Jun 2011
Sato Tadashi, Liu Xiangde, Basma Hesham, Togo Shinsaku, Sugiura Hisatoshi, Nelson Amy, Nakanishi Masanori, Kanaji Nobuhiro, Wang Xingqi, Kim Miok, Li Yingji, Michalski Joel, Farid Maha, Sharp John G, Rennard Stephen I
Abstract excerpt
BACKGROUND: Fibroblast heterogeneity is recognized, and fibroblasts from diseased tissues, including those of asthmatic subjects, have functional phenotypes that differ from normal tissue. However, progenitor-progeny relationships and the factors that control fibroblast differentiation are poorly defined. OBJECTIVE: We sought to determine whether IL-4 could alter the functional phenotype of fibroblasts during...
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