Article
Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.
Journal of virology - 1 Jul 2013
Ping Li-Hua, Joseph Sarah B, Anderson Jeffrey A, Abrahams Melissa-Rose, Salazar-Gonzalez Jesus F, Kincer Laura P, Treurnicht Florette K, Arney Leslie, Ojeda Suany, Zhang Ming, Keys Jessica, Potter E Lake, Chu Haitao, Moore Penny, Salazar Maria G, Iyer Shilpa, Jabara Cassandra, Kirchherr Jennifer, Mapanje Clement, Ngandu Nobubelo, Seoighe Cathal, Hoffman Irving, Gao Feng, Tang Yuyang, Labranche Celia, Lee Benhur, Saville Andrew, Vermeulen Marion, Fiscus Susan, Morris Lynn, Karim Salim Abdool, Haynes Barton F, Shaw George M, Korber Bette T, Hahn Beatrice H, Cohen Myron S, Montefiori David, Williamson Carolyn, Swanstrom Ronald
Abstract excerpt
Understanding human immunodeficiency virus type 1 (HIV-1) transmission is central to developing effective prevention strategies, including a vaccine. We compared phenotypic and genetic variation in HIV-1 env genes from subjects in acute/early infection and subjects with chronic infections in the context of subtype C heterosexual transmission. We found that the transmitted viruses all used CCR5 and required high...
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