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Article

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120

20 Feb 2018

Abstract excerpt

The HIV-1 envelope protein (Env) of early-replicating viruses encodes several distinct transmission signatures. One such signature involves a reduced number of potential N-linked glycosylation sites (PNGs). This transmission signature underscores the importance of posttranslational modifications in the fitness of early-replicating isolates. An additional signature in Env involves the overrepresentation of basic...

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PMID: 29463753
DOI: 10.1073/pnas.1722627115

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