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Article

The genetics of ATP-binding cassette transporters.

Methods in enzymology - 1 Jan 2005

Dean Michael

Abstract excerpt

The ATP-binding cassette (ABC) superfamily consists of membrane proteins that transport a wide variety of substrates across membranes. Mutations in ABC transporters cause or contribute to a number of different Mendelian disorders, including adrenoleukodystrophy, cystic fibrosis, retinal degeneration, cholesterol, and bile transport defects. In addition, the genes are involved in an increasing number of complex...

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PMID: 16399363
DOI: 10.1016/S0076-6879(05)00024-8

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