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Article

A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing

8 Mar 2011

Abstract excerpt

The human naive T cell repertoire is the repository of a vast array of TCRs. However, the factors that shape their hierarchical distribution and relationship with the memory repertoire remain poorly understood. In this study, we used polychromatic flow cytometry to isolate highly pure memory and naive CD8(+) T cells, stringently defined with multiple phenotypic markers, and used deep sequencing to characterize...

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PMID: 21383244
DOI: 10.4049/jimmunol.1003898

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