Article
Evidence on how a conserved glycine in the hinge region of HapR regulates its DNA binding ability: lessons from a natural variant.
The Journal of biological chemistry - 29 Apr 2011
Dongre Mitesh, Singh Naorem Santa, Dureja Chetna, Peddada Nagesh, Solanki Ashish K, Ashish, Raychaudhuri Saumya
Abstract excerpt
HapR has been recognized as a quorum-sensing master regulator in Vibrio cholerae. Because it controls a plethora of disparate cellular events, the absence of a functional HapR affects the physiology of V. cholerae to a great extent. In the current study, we pursued an understanding of an observation of a natural protease-deficient non-O1, non-O139 variant V. cholerae strain V2. Intriguingly, a nonfunctional HapR...
Topics
- Bacterial Proteins
- DNA
- DNA-Binding Proteins
- Genetic Variation
- Glycine
- Protein Structure, Secondary
- Quorum Sensing
- Vibrio cholerae