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Article

The hydrogen peroxide hypersensitivity of OxyR2 in Vibrio vulnificus depends on conformational constraints.

The Journal of biological chemistry - 28 Apr 2017

Jo Inseong, Kim Dukyun, Bang Ye-Ji, Ahn Jinsook, Choi Sang Ho, Ha Nam-Chul

Abstract excerpt

Most Gram-negative bacteria respond to excessive levels of H2O2 using the peroxide-sensing transcriptional regulator OxyR, which can induce the expression of antioxidant genes to restore normality. Vibrio vulnificus has two distinct OxyRs (OxyR1 and OxyR2), which are sensitive to different levels of H2O2 and induce expression of two different peroxidases, Prx1 and Prx2. Although OxyR1 has both high sequence...

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Identifiers

PMID: 28264933
DOI: 10.1074/jbc.M116.743765
PMCID: PMC5409488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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