Exploring Computational and Biophysical Tools to Study the Presence of G-Quadruplex Structures: A Promising Therapeutic Solution for Drug-Resistant Vibrio cholerae

Abstract excerpt

Vibrio cholera, a gram-negative bacterium that causes cholera has already caused seven major pandemics across the world and infects 1.3 to 4 million people every year. The cholera treatment primarily involves oral rehydration therapy supplemented with antibiotics. But recently, multidrug-resistant strains of V. cholerae has emerged. High genomic plasticity further enhances the pathogenesis of this human pathogen....