Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells

4 Mar 2011

Abstract excerpt

An early substantial loss of basal forebrain cholinergic neurons (BFCN) is a constant feature of Alzheimer's disease and is associated with deficits in spatial learning and memory. The ability to selectively control the differentiation of human embryonic stem cells (hESCs) into BFCN would be a significant step toward a cell replacement therapy. We demonstrate here a method for the derivation of a predominantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholinesterase and Neurodegenerative Diseases
Share to Neuroscience and Neural Engineering
Share to Pluripotent Stem Cells Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21381151
DOI: 10.1002/stem.626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem CellsPMID 21381151Read ↗

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-derived Basal Forebrain Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease ModelingSemantic proximity Read ↗

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease ModelingSemantic proximity Read ↗

Rapid single-step induction of functional neurons from human pluripotent stem cells.Semantic proximity Read ↗

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.Semantic proximity Read ↗

Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells.Semantic proximity Read ↗

Aging-Relevant Human Basal Forebrain Cholinergic Neurons as a Cell Model for Alzheimer’s DiseaseSemantic proximity Read ↗

Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications.Semantic proximity Read ↗

A human iPS cell line for ready-to-use human iAstrocytes that support human neuronsSemantic proximity Read ↗

Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditions.Semantic proximity Read ↗

Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.Semantic proximity Read ↗

Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells.Semantic proximity Read ↗

Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell LinesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.