Article
Rapid single-step induction of functional neurons from human pluripotent stem cells.
Neuron - 5 Jun 2013
Zhang Yingsha, Pak Changhui, Han Yan, Ahlenius Henrik, Zhang Zhenjie, Chanda Soham, Marro Samuele, Patzke Christopher, Acuna Claudio, Covy Jason, Xu Wei, Yang Nan, Danko Tamas, Chen Lu, Wernig Marius, Südhof Thomas C
Abstract excerpt
Available methods for differentiating human embryonic stem cells (ESCs) and induced pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable. Alternatively, human fibroblasts can be directly converted into induced neuronal (iN) cells. However, with present techniques conversion is inefficient, synapse formation is limited, and only small amounts of neurons can be generated. Here, we show...
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