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Article

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.

Nature neuroscience - 1 Dec 2002

Wu Ping, Tarasenko Yevgeniya I, Gu Yanping, Huang Li-Yen M, Coggeshall Richard E, Yu Yongjia

Abstract excerpt

Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle, however, is that the majority of such cells do not differentiate into neurons when grafted into non-neurogenic areas of the adult CNS. Here we report a new in vitro priming procedure that generates a nearly pure population of neurons from...

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PMID: 12426573
DOI: 10.1038/nn974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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