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Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells.

Stem cell reports - 8 Nov 2016

Chi Liankai, Fan Beibei, Zhang Kunshan, Du Yanhua, Liu Zhongliang, Fang Yujiang, Chen Zhenyu, Ren Xudong, Xu Xiangjie, Jiang Cizhong, Li Siguang, Ma Lin, Gao Liang, Liu Ling, Zhang Xiaoqing

Abstract excerpt

Embryoid body (EB) formation and adherent culture (AD) paradigms are equivalently thought to be applicable for neural specification of human pluripotent stem cells. Here, we report that sonic hedgehog-induced ventral neuroprogenitors under EB conditions are fated to medial ganglionic eminence (MGE), while the AD cells mostly adopt a floor-plate (FP) fate. The EB-MGE later on differentiates into GABA and...

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PMID: 27720902
DOI: 10.1016/j.stemcr.2016.09.003
PMCID: PMC5106484

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STAT3

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