Article
Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.
Blood - 3 Mar 2011
England Samantha J, McGrath Kathleen E, Frame Jenna M, Palis James
Abstract excerpt
In the hematopoietic hierarchy, only stem cells are thought to be capable of long-term self-renewal. Erythroid progenitors derived from fetal or adult mammalian hematopoietic tissues are capable of short-term, or restricted (10(2)- to 10(5)-fold), ex vivo expansion in the presence of erythropoietin, stem cell factor, and dexamethasone. Here, we report that primary erythroid precursors derived from early mouse...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Proliferation
- Cell Size
- Cell Survival
- Cells, Cultured
- Cytokines
- Dexamethasone
- Erythroblasts
- Fetus
- Humans
- Liver
- Mammals
- Mice
- Mice, Inbred C57BL