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Article

T1α/podoplanin is essential for capillary morphogenesis in lymphatic endothelial cells

26 Jul 2008

Abstract excerpt

The lymphatic vasculature functions to maintain tissue perfusion homeostasis. Defects in its formation or disruption of the vessels result in lymphedema, the effective treatment of which is hampered by limited understanding of factors regulating lymph vessel formation. Mice lacking T1alpha/podoplanin, a lymphatic endothelial cell transmembrane protein, have malformed lymphatic vasculature with lymphedema at...

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PMID: 18658274
DOI: 10.1152/ajplung.90262.2008

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