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Article

Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 1999

Gautreau A, Poullet P, Louvard D, Arpin M

Abstract excerpt

ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane. We have investigated ezrin function in tubulogenesis of a kidney-derived epithelial cell line, LLC-PK1. Here we show that cells overproducing a mutant form of ezrin in which Tyr-353 was changed to a phenylalanine (Y353F) undergo apoptosis when...

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Identifiers

PMID: 10377409
DOI: 10.1073/pnas.96.13.7300
PMCID: PMC22080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway.PMID 10377409Read ↗

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A glimpse of the ERM proteinsSemantic proximity Read ↗

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Identification and relevance of the CD95-binding domain in the N-terminal region of ezrin.Semantic proximity Read ↗

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin FamilySemantic proximity Read ↗

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