Article
Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays.
Genomics - 1 Jun 2011
LeBron Cynthia, Pal Prodipto, Brait Mariana, Dasgupta Santanu, Guerrero-Preston Rafael, Looijenga Leendert H J, Kowalski Jeanne, Netto George, Hoque Mohammad O
Abstract excerpt
Testicular germ cell tumors (TGCT) represent the most common malignancy among young males. To our knowledge no comprehensive Copy Number Variation (CNVs) studies of TGCT using high-resolution Single Nucleotide Polymorphism (SNP) array have been performed. By a genome-wide analysis of CNV and loss of heterozygosity (LOH) in 25 primary seminomas, we confirmed several previously reported genomic alterations and...
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