Article
Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2021
Rizzo Natalie M, Sholl Lynette M, Idrees Muhammad T, Cheville John C, Gupta Sounak, Cornejo Kristine M, Miyamoto Hiroshi, Hirsch Michelle S, Collins Katrina, Acosta Andrés M
Abstract excerpt
Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5-10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with...
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