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Article

Flexible design for following up positive findings.

American journal of human genetics - 1 Sept 2007

Yu Kai, Chatterjee Nilanjan, Wheeler William, Li Qizhai, Wang Sophia, Rothman Nathaniel, Wacholder Sholom

Abstract excerpt

As more population-based studies suggest associations between genetic variants and disease risk, there is a need to improve the design of follow-up studies (stage II) in independent samples to confirm evidence of association observed at the initial stage (stage I). We propose to use flexible designs developed for randomized clinical trials in the calculation of sample size for follow-up studies. We apply a...

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Identifiers

PMID: 17701899
DOI: 10.1086/520678
PMCID: PMC1950823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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