Article
Probability of detecting disease-associated single nucleotide polymorphisms in case-control genome-wide association studies.
Biostatistics (Oxford, England) - 1 Apr 2008
Gail Mitchell H, Pfeiffer Ruth M, Wheeler William, Pee David
Abstract excerpt
Some case-control genome-wide association studies (CCGWASs) select promising single nucleotide polymorphisms (SNPs) by ranking corresponding p-values, rather than by applying the same p-value threshold to each SNP. For such a study, we define the detection probability (DP) for a specific disease-associated SNP as the probability that the SNP will be "T-selected," namely have one of the top T largest chi-square...
Topics
Join the communities discussing this publication.