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Article

Functional three-domain single-chain T-cell receptors.

20 Dec 1994

Abstract excerpt

T-cell receptors (TCRs) are membrane anchored heterodimers structurally related to antibody molecules. Single-chain antibodies can be engineered by linking the two variable domains, which fold properly by themselves. However, proper assembly of the variable domains of a human TCR (V alpha and V beta) that recognize the HLA-DR2b/myelin basic protein-(85-99) peptide complex was critically dependent on the addition...

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Identifiers

PMID: 7809095
DOI: 10.1073/pnas.91.26.12654

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