Article
Prediction of inter-individual variability in the pharmacokinetics of CYP2C19 substrates in humans.
Drug metabolism and pharmacokinetics - 1 Jan 2014
Chiba Koji, Shimizu Keiko, Kato Motohiro, Nishibayashi Takaaki, Terada Kazuki, Izumo Nobuo, Sugiyama Yuichi
Abstract excerpt
Significant inter-individual variability of exposure for CYP2C19 substrates may be only partly due to genetic polymorphism. Therefore, the in vivo inter-individual variability in hepatic intrinsic clearance (CL(int,h)) of CYP2C19 substrates was estimated from reported AUC values using Monte Carlo simulations. The coefficient of variation (CV) for CL(int,h) in poor metabolizers (PM) expected from genotypes...
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