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Article

Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype.

European journal of clinical pharmacology - 1 Feb 2006

Qiao Hai-Ling, Hu Yu-Rong, Tian Xin, Jia Lin-Jing, Gao Na, Zhang Li-Rong, Guo Yu-Zhong

Abstract excerpt

OBJECTIVE: Omeprazole, lansoprazole and rabeprazole have been widely used as proton pump inhibitors (PPIs). They can be metabolized in the liver by CYP2C19, a polymorphic enzyme, and have a wide inter-individual variability with respect to drug response. In the investigation reported here, we examined the kinetic characteristics of the three PPIs in healthy Chinese subjects in relation to CYP2C19 genotype status....

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Identifiers

PMID: 16402242
DOI: 10.1007/s00228-005-0063-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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