Article
Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype.
European journal of clinical pharmacology - 1 Feb 2006
Qiao Hai-Ling, Hu Yu-Rong, Tian Xin, Jia Lin-Jing, Gao Na, Zhang Li-Rong, Guo Yu-Zhong
Abstract excerpt
OBJECTIVE: Omeprazole, lansoprazole and rabeprazole have been widely used as proton pump inhibitors (PPIs). They can be metabolized in the liver by CYP2C19, a polymorphic enzyme, and have a wide inter-individual variability with respect to drug response. In the investigation reported here, we exa...
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