Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.

doi:10.1037/a0027471

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Article

Interaction between serotonin transporter polymorphism (5-HTTLPR) and stressful life events in adolescents' trajectories of anxious/depressed symptoms.

Developmental psychology - 1 Sept 2012

Petersen Isaac T, Bates John E, Goodnight Jackson A, Dodge Kenneth A, Lansford Jennifer E, Pettit Gregory S, Latendresse Shawn J, Dick Danielle M

Abstract excerpt

Caspi et al. (2003) found an interaction between the serotonin transporter polymorphism gene (5-HTTLPR) and stressful life events on depression. Subsequent attempts to replicate have been inconsistent. The present research included long allele variants modified by SNP rs25531 and tested the interaction on adolescents' trajectories of anxious/depressed symptoms, with consideration of possible age effects....

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PMID: 22390669
DOI: 10.1037/a0027471
PMCID: PMC3404160

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