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Article

PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2.

The Journal of general virology - 1 Jun 2011

Li Jing, Li Yongqiang, Hu Yi, Chang Guohui, Sun Wei, Yang Yinhui, Kang Xiaoping, Wu Xiaoyan, Zhu Qingyu

Abstract excerpt

H5N1 avian influenza viruses demonstrate different phenotypes, such as pathogenicity after one or serial passages in mammalian hosts or cells. To establish the molecular basis of these phenotypes, we cloned isolates from the lungs of mice infected with human A/Vietnam/1194/2004 (H5N1) influenza virus. Large-plaque isolates were less pathogenic to mice than small-plaque isolates. Genome sequencing revealed that...

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Identifiers

PMID: 21367983
DOI: 10.1099/vir.0.030718-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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