Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

11 Aug 2011

Abstract excerpt

Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathogenicity factor. A full-length PB1-F2 has been present in all human influenza pandemic virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21852950
DOI: 10.1371/journal.ppat.1002186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian SpeciesPMID 21852950Read ↗

Non-Avian Animal Reservoirs Present a Source of Influenza A PB1-F2 Proteins with Novel Virulence-Enhancing MarkersSemantic proximity Read ↗

Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses.Semantic proximity Read ↗

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.Semantic proximity Read ↗

Emergence of Highly Pathogenic Avian Influenza A(H5N1) Virus PB1-F2 Variants and Their Virulence in BALB/c MiceSemantic proximity Read ↗

Kinetic Characterization of PB1-F2-Mediated Immunopathology during Highly Pathogenic Avian H5N1 Influenza Virus InfectionSemantic proximity Read ↗

A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence.Semantic proximity Read ↗

Evolution and Virulence of Influenza A Virus Protein PB1-F2Semantic proximity Read ↗

PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens.Semantic proximity Read ↗

Is PB1-F2 a virulence factor for avian influenza virus in poultry?Semantic proximity Read ↗

The PB2 mutation with lysine at 627 enhances the pathogenicity of avian influenza (H7N9) virus which belongs to a non-zoonotic lineageSemantic proximity Read ↗

Study of the host specificity of PB1-F2-associated virulenceSemantic proximity Read ↗

Differential localization and function of PB1-F2 derived from different strains of influenza A virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.