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Article

Substitutions in the PB2 methionine 283 residue affect H5 subtype avian influenza virus virulence.

Transboundary and emerging diseases - 1 Nov 2020

Chen Sujuan, Xie Yizhang, Su Xiang, Xue Jing, Wang Xiao, Du Yinping, Qin Tao, Peng Daxin, Liu Xiufan

Abstract excerpt

The influenza A virus (IAV) PB2 subunit modulates viral polymerase activity, replication kinetics and pathogenicity. Here we identified novel PB2 substitutions at position 283 of H5 subtype IAV and evaluated their biological characteristics and virulence. The substitution PB2-M283L enhanced the growth capacity and polymerase activity in human and mammalian cells in comparison to the rWT virus. The substitution...

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PMID: 32351035
DOI: 10.1111/tbed.13601

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