Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.

DNA research : an international journal for rapid publication of reports on genes and genomes - 1 Apr 2010

Tindall Elizabeth A, Hayes Vanessa M

Abstract excerpt

A newly described heterodimeric cytokine, interleukin-23 (IL-23) is emerging as a key player in both the innate and the adaptive T helper (Th)17 driven immune response as well as an initiator of several autoimmune diseases. The rate-limiting element of IL-23 production is believed to be driven by expression of the unique p19 subunit encoded by IL23A. We set out to perform comprehensive DNA sequencing of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Phylogeny

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 20154336
DOI: 10.1093/dnares/dsq003
PMCID: PMC2853383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive sequence analysis of the human IL23A gene defines new variation content and high rate of evolutionary conservation.PMID 20154336Read ↗

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans.Semantic proximity Read ↗

Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.Semantic proximity Read ↗

Brief report: high-throughput sequencing of IL23R reveals a low-frequency, nonsynonymous single-nucleotide polymorphism that is associated with ankylosing spondylitis in a Han Chinese population.Semantic proximity Read ↗

Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review.Semantic proximity Read ↗

Identification and characterization of multiple splice forms of the human interleukin-23 receptor alpha chain in mitogen-activated leukocytes.Semantic proximity Read ↗

Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases.Semantic proximity Read ↗

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses.Semantic proximity Read ↗

IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cellsSemantic proximity Read ↗

Haplotype structure and evidence for positive selection at the human IL13 locus.Semantic proximity Read ↗

In Silico Identification and Structural Characterization of High-Risk Missense SNVs in the Human IL23R Gene Relevant to Inflammatory Bowel Disease.Semantic proximity Read ↗

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in PsoriasisSemantic proximity Read ↗

Homozygosity for the Common IL23R R381Q Variant Associates with Increased Susceptibility to Chronic Mucocutaneous Candidiasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.