Article
Is lipid flippase activity of SNARE transmembrane domains required for membrane fusion?
FEBS letters - 6 Apr 2011
Langer Marcella, Langosch Dieter
Abstract excerpt
It has been suggested that lipids translocate between the outer and inner leaflets of fusing membranes, or flip-flop, to facilitate changes in bilayer leaflet areas at various stages of fusion. Here, we investigated the lipid flip activity of synthetic peptides that mimic SNARE transmembrane domains (TMDs). These peptides indeed induce flip of marker lipids. However, mutations that reduce flip activity do not...
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