Article
pH-dependent promotion of phospholipid flip-flop by the KcsA potassium channel.
Biochimica et biophysica acta - 1 Jan 2015
Nakao Hiroyuki, Ikeda Keisuke, Iwamoto Masayuki, Shimizu Hirofumi, Oiki Shigetoshi, Ishihama Yasushi, Nakano Minoru
Abstract excerpt
KcsA is a pH-dependent potassium channel that is activated at acidic pH. The channel undergoes global conformational changes upon activation. We hypothesized that the open-close conformational changes of the transmem brane region could promote the flip-flop of phosphoiipids. Based on this hypothesis, we measured the flip-flop ofNBD-labeled phospholipids in KcsA-incorporated proteoliposomes. Both flip and flop...
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