Article
Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells.
Pigment cell & melanoma research - 1 Jun 2011
Smith Aaron G, Lim Wen, Pearen Michael, Muscat George E O, Sturm Richard A
Abstract excerpt
Activating mutations in the MAPK pathway effectors, NRAS or BRAF, are detected in over 70% of melanomas. Accordingly, the identification of downstream targets of constitutive MAPK signalling in melanoma represents a major goal in understanding the genesis of this disease. We report here the regulation of members of the NR4A family of nuclear receptors by the BRAF-MEK-ERK cascade in melanoma cells. Expression...
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