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Article

MUC1 intra-cellular trafficking is clathrin, dynamin, and rab5 dependent.

Biochemical and biophysical research communications - 28 Nov 2008

Liu Xiaolong, Yuan Zhenglong, Chung Maureen

Abstract excerpt

MUC1, a transmembrane glycoprotein, is abnormally over-expressed in most human adenocarcinomas. MUC1 association with cytoplasmic cell signal regulators and nuclear accumulation are important for its tumor related activities. Little is known about how MUC1 translocates from the cell membrane to the cytoplasm. In this study, live cell imaging was used to study MUC1 intracellular trafficking. The interaction...

Topics

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Clathrin
Cricetulus
Dynamins
Endocytosis
Epidermal Growth Factor
Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rab5 GTP-Binding Proteins

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Identifiers

PMID: 18812166
DOI: 10.1016/j.bbrc.2008.09.065

Genes

MUC1
EGFR
EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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