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Article

Chemokine receptor CXCR2 mediates bacterial clearance rather than neutrophil recruitment in a murine model of pneumonic plague.

The American journal of pathology - 1 Mar 2011

Eisele Nicholas A, Lee-Lewis Hanni, Besch-Williford Cynthia, Brown Charles R, Anderson Deborah M

Abstract excerpt

Pulmonary infection by Yersinia pestis causes pneumonic plague, a necrotic bronchopneumonia that is rapidly lethal and highly contagious. Acute pneumonic plague accompanies the up-regulation of pro-inflammatory cytokines and chemokines, suggesting that the host innate immune response may contribute to the development of disease. To address this possibility, we sought to understand the consequences of neutrophil...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21356370
DOI: 10.1016/j.ajpath.2010.11.067
PMCID: PMC3070576

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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