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Article

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.

BMC cancer - 9 Oct 2006

Broderick Peter, Bagratuni Tina, Vijayakrishnan Jairam, Lubbe Steven, Chandler Ian, Houlston Richard S

Abstract excerpt

BACKGROUND: The observation that germline mutations in the oxidative DNA damage repair gene MUTYH cause colorectal cancer (CRC) provides strong evidence that dysregulation of the base excision repair (BER) pathway influences disease susceptibility. It is conceivable that germline sequence variati...

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Source

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Identifiers

PMID: 17029639
DOI: 10.1186/1471-2407-6-243
PMCID: PMC1624846

Genes

NEIL2
TDG
UNG
MPG
NEIL1
NTHL1
SMUG1
MUTYH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17029639-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.PMID 17029639Read ↗

Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.Semantic proximity Read ↗

NTHL1 and MUTYH polyposis syndromes: two sides of the same coin?Semantic proximity Read ↗

A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer.Semantic proximity Read ↗

Genotype-phenotype correlations in NTHL1-associated tumour syndrome: case report and literature review.Semantic proximity Read ↗

NTHL1 in genomic integrity, aging and cancer.Semantic proximity Read ↗

Evaluation of the association of heterozygous germline variants in NTHL1 with breast cancer predisposition: an international multi-center study of 47,180 subjectsSemantic proximity Read ↗

Analysis of the oxidative damage repair genes NUDT1, OGG1, and MUTYH in patients from mismatch repair proficient HNPCC families (MSS-HNPCC).Semantic proximity Read ↗

MBD4-associated neoplasia syndrome: screening of cases with suggestive phenotypes.Semantic proximity Read ↗

Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.Semantic proximity Read ↗

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer PatientsSemantic proximity Read ↗

Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma.Semantic proximity Read ↗

Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical OutcomeSemantic proximity Read ↗

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