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Article

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

Developmental cell - 12 Jun 2012

Barak Hila, Huh Sung-Ho, Chen Shuang, Jeanpierre Cécile, Martinovic Jelena, Parisot Mélanie, Bole-Feysot Christine, Nitschké Patrick, Salomon Rémi, Antignac Corinne, Ornitz David M, Kopan Raphael

Abstract excerpt

The identity of niche signals necessary to maintain embryonic nephron progenitors is unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient to maintain progenitor stemness. Reduction in the lev...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22698282
DOI: 10.1016/j.devcel.2012.04.018
PMCID: PMC3376351

Genes

FGF20
FGF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22698282-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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