Article
Real-time PCR methods to study expression of genes related to hypermutability.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
O'Sullivan Denise M
Abstract excerpt
Pathogenic bacteria can have sub-populations of hypermutable bacteria. This sub-population has a higher spontaneous mutation rate than the majority of the population which can be attributed to defects in proofreading and repair mechanisms. This leads to the evolution of drug-resistant strains of bacteria through genetic change. It is important to study the expression of genes involved in, for example, mismatch...
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