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Article

Cytotoxicity of an anti-cancer lysophospholipid through selective modification of lipid raft composition.

The Journal of biological chemistry - 11 Nov 2005

Zaremberg Vanina, Gajate Consuelo, Cacharro Luis M, Mollinedo Faustino, McMaster Christopher R

Abstract excerpt

Edelfosine is a prototypical member of the alkylphosphocholine class of antitumor drugs. Saccharomyces cerevisiae was used to screen for genes that modulate edelfosine cytotoxicity and identified sterol and sphingolipid pathways as relevant regulators. Edelfosine addition to yeast resulted in the selective partitioning of the essential plasma membrane protein Pma1p out of lipid rafts. Microscopic analysis...

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Identifiers

PMID: 16155007
DOI: 10.1074/jbc.M502849200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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