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Article

The choice of null distributions for detecting gene-gene interactions in genome-wide association studies.

BMC bioinformatics - 15 Feb 2011

Yang Can, Wan Xiang, He Zengyou, Yang Qiang, Xue Hong, Yu Weichuan

Abstract excerpt

BACKGROUND: In genome-wide association studies (GWAS), the number of single-nucleotide polymorphisms (SNPs) typically ranges between 500,000 and 1,000,000. Accordingly, detecting gene-gene interactions in GWAS is computationally challenging because it involves hundreds of billions of SNP pairs. Stage-wise strategies are often used to overcome the computational difficulty. In the first stage, fast screening...

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Identifiers

PMID: 21342556
DOI: 10.1186/1471-2105-12-S1-S26
PMCID: PMC3044281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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