Article
Enhancing the prioritization of disease-causing genes through tissue specific protein interaction networks.
PLoS computational biology - 1 Jan 2012
Magger Oded, Waldman Yedael Y, Ruppin Eytan, Sharan Roded
Abstract excerpt
The prioritization of candidate disease-causing genes is a fundamental challenge in the post-genomic era. Current state of the art methods exploit a protein-protein interaction (PPI) network for this task. They are based on the observation that genes causing phenotypically-similar diseases tend to lie close to one another in a PPI network. However, to date, these methods have used a static picture of human PPIs,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.