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Article

Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

22 Feb 2011

Abstract excerpt

BACKGROUND: Cancer stem cells (CSCs) play an important role in the development and recurrence of malignant tumors including glioma. Notch signaling, an evolutionarily conserved pathway mediating direct cell-cell interaction, has been shown to regulate neural stem cells (NSCs) and glioma stem cells (GSCs) in normal neurogenesis and pathological carcinogenesis, respectively. However, how Notch signaling regulates...

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PMID: 21342503
DOI: 10.1186/1471-2407-11-82

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