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γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft Recurrence

24 Aug 2010

Abstract excerpt

Malignant gliomas are treated with a combination of surgery, radiation, and temozolomide (TMZ), but these therapies ultimately fail due to tumor recurrence. In glioma cultures, TMZ treatment significantly decreases neurosphere formation; however, a small percentage of cells survive and repopulate the culture. A promising target for glioma therapy is the Notch signaling pathway. Notch activity is upregulated in...

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PMID: 20736377
DOI: 10.1158/0008-5472.can-10-1378

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Research trail→

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γ-Secretase Inhibitors Enhance Temozolomide Treatment of Human Gliomas by Inhibiting Neurosphere Repopulation and Xenograft RecurrencePMID 20736377Read ↗

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The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic ResistanceSemantic proximity Read ↗

hMSC-mediated Concurrent Delivery of Endostatin and Carboxylesterase to Mouse Xenografts Suppresses Glioma Initiation and RecurrenceSemantic proximity Read ↗

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastomaSemantic proximity Read ↗

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Inhibition of Notch Signaling in Glioblastoma Targets Cancer Stem Cells via an Endothelial Cell IntermediateSemantic proximity Read ↗

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