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Level of Notch activation determines the effect on growth and stem cell-like features in glioblastoma multiforme neurosphere cultures

10 Jul 2013

Abstract excerpt

BACKGROUND: Brain cancer stem-like cells (bCSC) are cancer cells with neural stem cell (NSC)-like properties found in glioblastoma multiforme (GBM) and they are assigned a central role in tumor initiation, progression and relapse. The Notch pathway is important for maintenance and cell fate decisions in the normal NSC population. Notch signaling is often deregulated in GBM and recent results suggest that this...

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PMID: 23792644
DOI: 10.4161/cbt.24595

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