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Article

IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena.

Journal of cell science - 15 Jun 2003

Nakagawa Hiroyuki, Miki Hiroaki, Nozumi Motohiro, Takenawa Tadaomi, Miyamoto Shigeaki, Wehland Jürgen, Small J Victor

Abstract excerpt

The insulin receptor tyrosine kinase substrate p53 (IRSp53) links Rac and WAVE2 and has been implicated in lamellipodia protrusion. Recently, however, IRSp53 has been reported to bind to both Cdc42 and Mena to induce filopodia. To shed independent light on IRSp53 function we determined the localisations and dynamics of IRSp53 and WAVE2 in B16 melanoma cells. In cells spread well on a laminin substrate, IRSp53 was...

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Identifiers

PMID: 12734400
DOI: 10.1242/jcs.00462

Genes

VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena.PMID 12734400Read ↗

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Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.Semantic proximity Read ↗

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WAVE3 Functions as a Negative Regulator of LDOC1Semantic proximity Read ↗

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