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Article

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.

The Journal of biological chemistry - 18 Jul 2008

Lim Kim Buay, Bu Wenyu, Goh Wah Ing, Koh Esther, Ong Siew Hwa, Pawson Tony, Sudhaharan Thankiah, Ahmed Sohail

Abstract excerpt

The Cdc42 effector IRSp53 is a strong inducer of filopodia formation and consists of an Src homology domain 3 (SH3), a potential WW-binding motif, a partial-Cdc42/Rac interacting binding region motif, and an Inverse-Bin-Amphiphysins-Rvs (I-BAR) domain. We show that IRSp53 interacts directly with neuronal Wiskott-Aldrich syndrome protein (N-WASP) via its SH3 domain and furthermore that N-WASP is required for...

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Source

Identifiers

PMID: 18448434
DOI: 10.1074/jbc.M710185200

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.PMID 18448434Read ↗

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