Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.

Protein & cell - 1 Jan 2011

Lu Guangwen, Zhang Jie, Li Yan, Li Zhixin, Zhang Na, Xu Xiang, Wang Tingting, Guan Zhenhong, Gao George F, Yan Jinghua

Abstract excerpt

Human NUDT16 (hNUDT16) is a decapping enzyme initially identified as the human homolog to the Xenopus laevis X29. As a metalloenzyme, hNUDT16 relies on divalent cations for its cap-hydrolysis activity to remove m⁷GDP and m²²⁷GDP from RNAs. Metal also determines substrate specificity of the enzyme. So far, only U8 small nucleolar RNA (snoRNA) has been identified as the substrate of hNUDT16 in the presence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biocatalysis
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanosine Diphosphate

Share to Magnesium

Share to Manganese

Share to Pyrophosphatases

Share to RNA Caps

Share to RNA, Small Nucleolar

Source

Open in PubMed Open full text

Identifiers

PMID: 21337011
DOI: 10.1007/s13238-011-1009-2
PMCID: PMC4875290

Genes

NUDT16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA.PMID 21337011Read ↗

Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.Semantic proximity Read ↗

Fault-Tolerance Study on a Positive-Charged Cleft in 18S rRNA Methyltransferase DIMT1.Semantic proximity Read ↗

Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide dinucleotide metabolitesSemantic proximity Read ↗

Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease.Semantic proximity Read ↗

The Drosophila orthologue of progeroid human WRN exonuclease, DmWRNexo, cleaves replication substrates but is inhibited by uracil or abasic sites : analysis of DmWRNexo activity in vitro.Semantic proximity Read ↗

Coordination of divalent metal ions in the active site of poly(A)-specific ribonuclease.Semantic proximity Read ↗

How Do DICER1 Syndrome Mutations Disrupt Catalysis? Unveiling Dicer Metal Binding Architecture and Mechanism of Action Using MD Simulations and QM/MM Calculations.Semantic proximity Read ↗

Identification and <i>in vitro</i> characterization of UDP-GlcNAc-RNA cap-modifying and decapping enzymesSemantic proximity Read ↗

DDX3X is a Cl--sensitive RNA helicase.Semantic proximity Read ↗

Identification of functional domains in Arabidopsis thaliana mRNA decapping enzyme (AtDcp2).Semantic proximity Read ↗

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides.Semantic proximity Read ↗

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.