Article
Treatment of murine fulminant hepatitis with genetically engineered endothelial progenitor cells.
Journal of hepatology - 1 Oct 2011
Fernandez-Ruiz Veronica, Kawa Milosz, Berasain Carmen, Iñiguez Maria, Schmitz Volker, Martinez-Ansó Eduardo, Iñarrairaegui Mercedes, Herrero Ignacio, Sangro Bruno, D'Avola Delia, Quiroga Jorge, Qian Cheng, Prieto Jesus
Abstract excerpt
BACKGROUND & AIMS: Cell therapy has been used to attenuate liver injury. Here we evaluated whether genetic engineering of either bone marrow-derived mononuclear cells (MNC) or endothelial progenitor cells (EPC) many enhance their hepatoprotective properties. METHODS: Mice with ConA-induced hepatitis or with lethal fulminant hepatitis resulting from administration of an adenovirus encoding CD40L (AdCD40L) received...
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