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Article

Specific gene delivery to liver sinusoidal and artery endothelial cells

25 Jul 2013

Abstract excerpt

Different types of endothelial cells (EC) fulfill distinct tasks depending on their microenvironment. ECs are therefore difficult to genetically manipulate ex vivo for functional studies or gene therapy. We assessed lentiviral vectors (LVs) targeted to the EC surface marker CD105 for in vivo gene delivery. The mouse CD105-specific vector, mCD105-LV, transduced only CD105-positive cells in primary liver cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23884859
DOI: 10.1182/blood-2012-11-468579

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