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Article

Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K

18 Feb 2011

Abstract excerpt

3'-Methoxy-3,4',5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs. Isorhamnetin exerts anticancer effects, but the underlying molecular mechanism for the chemopreventive potential of isorhamnetin remains unknown. Here, we report anti-skin cancer effects of isorhamnetin, which inhibited epidermal growth factor (EGF)-induced neoplastic cell transformation. It also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21330379
DOI: 10.1158/1940-6207.capr-11-0032

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