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The Flavonol Isorhamnetin Exhibits Cytotoxic Effects on Human Colon Cancer Cells

5 Oct 2010

Abstract excerpt

The aim of this study was to determine whether isorhamnetin, an immediate 3'-O-methylated metabolite of quercetin, affects proliferation, cell death, and the cell cycle of human colon carcinoma (HCT-116) cells. Isorhamnetin was found to be a potent antiproliferative agent in a dose- and time-dependent manner, with an IC50 of 72 μM after 48 h of incubation as estimated by MTT assay. Flow cytometry and fluorescence...

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PMID: 20923189
DOI: 10.1021/jf102669p

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