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Article

Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid.

Biological & pharmaceutical bulletin - 1 Jan 2010

Endo Satoshi, Matsunaga Toshiyuki, Soda Midori, Tajima Kazuo, Zhao Hi-Tai, El-Kabbani Ossama, Hara Akira

Abstract excerpt

A human aldose reductase-like protein, AKR1B10 in the aldo-keto reductase (AKR) superfamily, was recently identified as a tumor marker of several types of cancer. Tolrestat, an aldose reductase inhibitor (ARI), is known to be the most potent inhibitor of the enzyme. In this study, we compared the inhibitory effects of other ARIs including flavonoids on AKR1B10 and aldose reductase to evaluate their specificity....

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Identifiers

PMID: 20460771
DOI: 10.1248/bpb.33.886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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